The VSU Main Campus is situated in Barangay Pangasugan, Baybay, City, Philippines. It is about 8 kilometers north of Baybay City and 34 kilometers south of Ormoc City. It is highly accessible by land and by sea from different parts of the province. An all-weather airport facility is located in Tacloban City, Leyte. Several inter-island passenger vessels including fast craft services ply from the ports of Baybay City, Bato, Hilongos, Maasin City, Ormoc City and Tacloban City to the major islands in the Visayas. 

VSU Main Campus has a total land area of 1,479.086 hectares that extends from the shores of Camotes Sea to the top of Mt. Pangasugan. Inside the campus are 188 buildings composed of academic departments, staff and student houses, the University Library, the Administration, Hostel, Convention Center, gymnasium and other structures. Also based within the campus are several research/training centers, namely: the Philippine Root Crop Research and Training Center (PhilRootcrops); National Abaca Research Center (NARC); National Coconut Research Center (NCRC) - Visayas; Farm and Resource Management Institute (FARMI); Philippine Carabao Center (PCC); and Agricultural Training Institute - National Training Center (ATI-NTC) - Visayas.